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Vulvo-vaginitis is a general term to describe all types of infection and inflammation of the vulvar, perineal and vaginal region. Inflammation can be caused by dermatologic disorders or by microbial infections. Dermatological infections include psoriasis, lichen sclerosis, lichen planus (or rubra), bulleous (pemphigomatous) vaginitis, desquamative inflammatory vaginitis (see also below in aerobic vaginitis), eczema, Bowen disease, plasma cell vaginitis, and pre-cancerous or cancerous lesions.

Infections of the vulvovaginal area can be divided in viral infections (herpes genitalis, human papilloma virus infection), bacterial infection (bacterial vaginosis, aerobic vagintis), yeast or mycotic infection (Candida albicans and other less frequent yeasts) and parasitic infection (Trichomonas vaginalis). Also, genital infections can occur concurrently with each other or with other infections of the genital tract such as cervicitis of pelvic inflammatory disease.